What is a common respiratory side effect of an ACE inhibitor overdose?

A common respiratory side effect of an ACE inhibitor overdose is coughing fits. ACE inhibitors are known to cause a persistent dry cough as a side effect due to their mechanism of action, which increases bradykinin levels. This can lead to heightened sensitivity in the respiratory tract, resulting in an irritating cough reflex.

In the context of an overdose, while symptoms might vary, coughing fits can become more pronounced due to the exacerbation of bradykinin-related effects. Wheezing and chest tightness are typically associated with bronchospasm or obstructive airway disease, which are not directly related to ACE inhibitor pharmacology. Difficult breathing with hives suggests an allergic reaction, which is not characteristic of ACE inhibitor effects. Therefore, coughing fits are the most consistent respiratory side effect linked to an invasive overdose scenario with an ACE inhibitor.