What is the maximum dose of naloxone for opioid overdose in adults?

The maximum dose of naloxone for treating opioid overdose in adults is important to understand for effective clinical management. The correct response indicates that naloxone can be administered at a dosage of 2 mg intranasally or 0.4 mg intramuscularly.

This dosing is based on established guidelines that aim to effectively reverse the effects of opioid overdose, particularly respiratory depression. When used intranasally, delivering 2 mg is a common practice because it allows for quick absorption through the nasal mucosa, which can be critical in emergency scenarios. Similarly, the intramuscular route of 0.4 mg is a recognized standard that can be repeated every 2 to 3 minutes if the patient's response is inadequate.

Understanding this dosing strategy is crucial as it balances the need for rapid reversal of opioid effects while minimizing the risk of potential side effects from too high a dose. The alternate choices suggest either incorrect maximum doses or routes that are not the preferred methods; for instance, subcutaneous and oral routes are not standard for naloxone administration in acute settings. Thus, knowing the correct maximum dose and the preferred administration routes is essential for paramedics and first responders dealing with opioid overdoses.