What pupil response is associated with an overdose of oxycodone?

Constricted pupils, also known as miosis, are a classic sign associated with an overdose of opioids, including oxycodone. This response occurs due to the way opioids interact with the central nervous system, specifically affecting the areas of the brain that control pupil dilation and constriction. Opioids bind to mu receptors, which leads to decreased sympathetic output and increased parasympathetic activity, resulting in the constriction of the pupils.

In the context of an oxycodone overdose, observing constricted pupils can be an important clinical indicator, especially when combined with other signs such as respiratory depression or altered mental status. This response can help healthcare providers identify the presence of an opioid overdose quickly, allowing for timely intervention and treatment.

In contrast, the other pupil responses listed would not typically be expected with an opioid overdose. Dilated pupils can indicate a range of other conditions or substance overdoses, normal pupils would not suggest any abnormality, and uneven pupils might suggest a neurological issue rather than an opioid effect.