Which of the following is a side effect of ACE inhibitors?

Angioedema is a known and significant side effect associated with ACE inhibitors. This condition involves the swelling of the deeper layers of the skin, often around the eyes and lips, and in some cases, it can affect the throat, posing potential risks for airway obstruction. Angioedema can occur suddenly and unpredictably, and while it may resolve on its own, it requires prompt medical intervention if it compromises breathing.

ACE inhibitors work by inhibiting the angiotensin-converting enzyme, which not only helps in lowering blood pressure but can also lead to increased bradykinin levels. High levels of bradykinin are thought to contribute to angioedema. It's crucial for healthcare providers to monitor patients on ACE inhibitors for signs of angioedema, especially at the start of treatment or after a dosage change, to ensure patient safety and effective management of this side effect.

In contrast, the other options do not typically relate to ACE inhibitors. Hypoglycemia is more commonly associated with diabetes medications, constipation may occur with various drugs but is not specifically linked to ACE inhibitors, and nervousness is not a direct side effect of these medications. Understanding these nuances helps in effectively managing patient care while utilizing ACE inhibitors for conditions such as hypertension and